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In /quote and /quoteBest you can pass a parameter showDangerousRoutes: false to filter routes with priceImpact more than -5% and less than +20% and slippage more than 20%(slippage: 0.2). Price impact is estimated as: 
srcTokenAmountInUsd = srcTokenAmount * srcTokenPrice
dstTokenAmountInUsd = dstTokenAmount * dstTokenPrice
priceImpact = ((srcTokenAmountInUsd - dstTokenAmountInUsd) / dstTokenAmountInUsd) * 100
By default showDangerousRoutes is optional property and set to false. If you pass showDangerousRoutes: true - you will receive in response every route that was successully found in spite of priceImpact and slippage values. Example of request to show only safe routes: 
{
    "dstTokenAddress":"0x1f9840a85d5af5bf1d1762f925bdaddc4201f984",
    "dstTokenBlockchain":"ETH",
    "integratorAddress":"0x3019BD6BA7CEE183298385958dDE8d67DfCc2340",
    "referrer":"arbitragescanner",
    "srcTokenAddress":"0xdac17f958d2ee523a2206206994597c13d831ec7",
    "srcTokenAmount":"100000000",
    "srcTokenBlockchain":"ETH",
    "showDangerousRoutes": false
}